S‐1 plus Raltitrexed for Refractory Metastatic Colorectal Cancer: A Phase II Trial

LESSONS LEARNED. The upregulation of dihydropyrimidine dehydrogenase (DPD) and thymidylate synthase (TS) are important mechanisms of resistance to 5‐fluorouracil (5‐FU) in metastatic colorectal cancer (mCRC) after long exposure to 5‐FU. S‐1 (containing a DPD inhibitor) combined with raltitrexed (a T...

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Detalles Bibliográficos
Autores principales: Chen, Ye, Wu, Jing, Cheng, Ke, Li, Zhi‐Ping, Luo, De‐Yun, Qiu, Meng, Gou, Hong‐Feng, Yi, Cheng, Li, Qiu, Wang, Xin, Yang, Yu, Cao, Dan, Shen, Ya‐Li, Bi, Feng, Liu, Ji‐Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Clinical Trial Results
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516113/
https://www.ncbi.nlm.nih.gov/pubmed/30651398
http://dx.doi.org/10.1634/theoncologist.2018-0901

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516113/
https://www.ncbi.nlm.nih.gov/pubmed/30651398
http://dx.doi.org/10.1634/theoncologist.2018-0901

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