NAD(+) supplementation rejuvenates aged gut adult stem cells

The tissue decline due to aging is associated with the deterioration of adult stem cell function. Here we show the number and proliferative activity of intestinal stem cells (ISCs) but not Paneth cells decline during aging, as does ISC function assessed ex vivo. Levels of SIRT1 and activity of mTORC...

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Detalles Bibliográficos
Autores principales: Igarashi, Masaki, Miura, Masaomi, Williams, Eric, Jaksch, Frank, Kadowaki, Takashi, Yamauchi, Toshimasa, Guarente, Leonard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516145/
https://www.ncbi.nlm.nih.gov/pubmed/30917412
http://dx.doi.org/10.1111/acel.12935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516145/
https://www.ncbi.nlm.nih.gov/pubmed/30917412
http://dx.doi.org/10.1111/acel.12935

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