Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational approaches to investigate mitochondrial health and bioenergetic function in neurons from a double transgenic animal model of AD (PS2APP...

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Detalles Bibliográficos
Autores principales: Theurey, Pierre, Connolly, Niamh M. C., Fortunati, Ilaria, Basso, Emy, Lauwen, Susette, Ferrante, Camilla, Moreira Pinho, Catarina, Joselin, Alvin, Gioran, Anna, Bano, Daniele, Park, David S., Ankarcrona, Maria, Pizzo, Paola, Prehn, Jochen H. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516149/
https://www.ncbi.nlm.nih.gov/pubmed/30793475
http://dx.doi.org/10.1111/acel.12924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516149/
https://www.ncbi.nlm.nih.gov/pubmed/30793475
http://dx.doi.org/10.1111/acel.12924

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