Cargando…

Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons

Mitochondrial dysfunction is implicated in most neurodegenerative diseases, including Alzheimer's disease (AD). We here combined experimental and computational approaches to investigate mitochondrial health and bioenergetic function in neurons from a double transgenic animal model of AD (PS2APP...

Descripción completa

Detalles Bibliográficos
Autores principales:	Theurey, Pierre, Connolly, Niamh M. C., Fortunati, Ilaria, Basso, Emy, Lauwen, Susette, Ferrante, Camilla, Moreira Pinho, Catarina, Joselin, Alvin, Gioran, Anna, Bano, Daniele, Park, David S., Ankarcrona, Maria, Pizzo, Paola, Prehn, Jochen H. M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516149/ https://www.ncbi.nlm.nih.gov/pubmed/30793475 http://dx.doi.org/10.1111/acel.12924

Ejemplares similares

Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling
por: Naia, Luana, et al.
Publicado: (2021)

The Aging Mitochondria
por: Theurey, Pierre, et al.
Publicado: (2018)

Mitofusin‐2 knockdown increases ER–mitochondria contact and decreases amyloid β‐peptide production
por: Leal, Nuno Santos, et al.
Publicado: (2016)

Glucose dysregulation in pre-clinical Alzheimer’s disease
por: Connolly, Niamh M. C., et al.
Publicado: (2019)

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
por: Connolly, Niamh M. C., et al.
Publicado: (2017)

A transcriptome-wide association study based on 27 tissues identifies 106 genes potentially relevant for disease pathology in age-related macular degeneration
por: Strunz, Tobias, et al.
Publicado: (2020)

Increased pro-MMP9 plasma levels are associated with neovascular age-related macular degeneration and with the risk allele of rs142450006 near MMP9
por: Lauwen, Susette, et al.
Publicado: (2021)

Mitochondria-Endoplasmic Reticulum Interplay Regulates Exo-Cytosis in Human Neuroblastoma Cells
por: Dentoni, Giacomo, et al.
Publicado: (2022)

Impaired mitochondrial respiration promotes dendritic branching via the AMPK signaling pathway
por: Gioran, A, et al.
Publicado: (2014)

Effects of Mild Excitotoxic Stimulus on Mitochondria Ca(2+) Handling in Hippocampal Cultures of a Mouse Model of Alzheimer’s Disease
por: Rigotto, Giulia, et al.
Publicado: (2021)

The Potential of Small Molecules to Modulate the Mitochondria–Endoplasmic Reticulum Interplay in Alzheimer’s Disease
por: Dentoni, Giacomo, et al.
Publicado: (2022)

Neuron-specific proteasome activation exerts cell non-autonomous protection against amyloid-beta (Aβ) proteotoxicity in Caenorhabditis elegans
por: Panagiotidou, Eleni, et al.
Publicado: (2023)

Analysis of hemopexin plasma levels in patients with age-related macular degeneration
por: Lauwen, Susette, et al.
Publicado: (2022)

Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy
por: Xu, Huan, et al.
Publicado: (2022)

Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer
por: Bano, Daniele, et al.
Publicado: (2018)

Hyperoxia Decreases Glycolytic Capacity, Glycolytic Reserve and Oxidative Phosphorylation in MLE-12 Cells and Inhibits Complex I and II Function, but Not Complex IV in Isolated Mouse Lung Mitochondria
por: Das, Kumuda C.
Publicado: (2013)

Distinct Pools of Non-Glycolytic Substrates Differentiate Brain Regions and Prime Region-Specific Responses of Mitochondria
por: Lee, Do Yup, et al.
Publicado: (2013)

TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation
por: Farina, Antonietta Rosella, et al.
Publicado: (2017)

Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells
por: Reda, Asmaa, et al.
Publicado: (2019)

Computational Analysis of AMPK-Mediated Neuroprotection Suggests Acute Excitotoxic Bioenergetics and Glucose Dynamics Are Regulated by a Minimal Set of Critical Reactions
por: Connolly, Niamh M. C., et al.
Publicado: (2016)

Transfer of a Redox-Signal through the Cytosol by Redox-Dependent Microcompartmentation of Glycolytic Enzymes at Mitochondria and Actin Cytoskeleton
por: Wojtera-Kwiczor, Joanna, et al.
Publicado: (2013)

Response of Coccomyxa cimbrica sp.nov. to Increasing Doses of Cu(II) as a Function of Time: Comparison between Exposure in a Microfluidic Device or with Standard Protocols
por: Speghini, Riccardo, et al.
Publicado: (2023)

Multi‐omics identify xanthine as a pro‐survival metabolite for nematodes with mitochondrial dysfunction
por: Gioran, Anna, et al.
Publicado: (2019)

HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways
por: Bao, Chuncha, et al.
Publicado: (2022)

A disease-associated Aifm1 variant induces severe myopathy in knockin mice
por: Wischhof, Lena, et al.
Publicado: (2018)

Mitochondrial Dysfunctions: A Thread Sewing Together Alzheimer's Disease, Diabetes, and Obesity
por: Rigotto, Giulia, et al.
Publicado: (2019)

PKM2: A Potential Regulator of Rheumatoid Arthritis via Glycolytic and Non-Glycolytic Pathways
por: Xu, Danyi, et al.
Publicado: (2019)

Reduction of PINK1 or DJ‐1 impair mitochondrial motility in neurites and alter ER‐mitochondria contacts
por: Parrado‐Fernández, Cristina, et al.
Publicado: (2018)

Influence of shear stress and size on viability of endothelial cells exposed to gold nanoparticles
por: Fede, C., et al.
Publicado: (2017)

Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform
por: Anilkumar, Ujval, et al.
Publicado: (2017)

Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment
por: Xintaropoulou, Chrysi, et al.
Publicado: (2018)

Physiological extremes of the human blood metabolome: A metabolomics analysis of highly glycolytic, oxidative, and anabolic athletes
por: Schranner, Daniela, et al.
Publicado: (2021)

High Resolution Measurement of the Glycolytic Rate
por: Bittner, Carla X., et al.
Publicado: (2010)

Glycolytic regulation of cell rearrangement in angiogenesis
por: Cruys, Bert, et al.
Publicado: (2016)

Glycolytic reliance promotes anabolism in photoreceptors
por: Chinchore, Yashodhan, et al.
Publicado: (2017)

Colorectal polyps increase the glycolytic activity
por: Rebane-Klemm, Egle, et al.
Publicado: (2023)

Moonlight functions of glycolytic enzymes in cancer
por: Shegay, Petr V., et al.
Publicado: (2023)

Phosphoglycerate Mutase 1: Its Glycolytic and Non-Glycolytic Roles in Tumor Malignant Behaviors and Potential Therapeutic Significance
por: Li, Na, et al.
Publicado: (2020)

Mediation of PKM2-dependent glycolytic and non-glycolytic pathways by ENO2 in head and neck cancer development
por: Gao, Lixia, et al.
Publicado: (2023)

Glycolytic Inhibitors Potentiated the Activity of Paclitaxel and Their Nanoencapsulation Increased Their Delivery in a Lung Cancer Model
por: Cunha, Andrea, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a5jsjsmispppng8omnadrh3a5t