Age‐associated cholesterol reduction triggers brain insulin resistance by facilitating ligand‐independent receptor activation and pathway desensitization

In the brain, insulin plays an important role in cognitive processes. During aging, these faculties decline, as does insulin signaling. The mechanism behind this last phenomenon is unclear. In recent studies, we reported that the mild and gradual loss of cholesterol in the synaptic fraction of hippo...

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Detalles Bibliográficos
Autores principales: Martín‐Segura, Adrián, Ahmed, Tariq, Casadomé‐Perales, Álvaro, Palomares‐Perez, Irene, Palomer, Ernest, Kerstens, Axelle, Munck, Sebastian, Balschun, Detlef, Dotti, Carlos G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516156/
https://www.ncbi.nlm.nih.gov/pubmed/30884121
http://dx.doi.org/10.1111/acel.12932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516156/
https://www.ncbi.nlm.nih.gov/pubmed/30884121
http://dx.doi.org/10.1111/acel.12932

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