Elimination of senescent osteoclast progenitors has no effect on the age‐associated loss of bone mass in mice

Both an increase in osteoclast and a decrease in osteoblast numbers contribute to skeletal aging. Markers of cellular senescence, including expression of the cyclin inhibitor p16, increase with aging in several bone cell populations. The elimination of p16‐expressing cells in old mice, using the INK...

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Detalles Bibliográficos
Autores principales: Kim, Ha‐Neui, Chang, Jianhui, Iyer, Srividhya, Han, Li, Campisi, Judith, Manolagas, Stavros C., Zhou, Daohong, Almeida, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516158/
https://www.ncbi.nlm.nih.gov/pubmed/30773784
http://dx.doi.org/10.1111/acel.12923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516158/
https://www.ncbi.nlm.nih.gov/pubmed/30773784
http://dx.doi.org/10.1111/acel.12923

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