Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease

Intron retention (IR) by alternative splicing is a conserved regulatory mechanism that can affect gene expression and protein function during adult development and age‐onset diseases. However, it remains unclear whether IR undergoes spatial or temporal changes during different stages of aging or neu...

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Detalles Bibliográficos
Autores principales: Adusumalli, Swarnaseetha, Ngian, Zhen‐Kai, Lin, Wei‐Qi, Benoukraf, Touati, Ong, Chin‐Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516162/
https://www.ncbi.nlm.nih.gov/pubmed/30868713
http://dx.doi.org/10.1111/acel.12928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516162/
https://www.ncbi.nlm.nih.gov/pubmed/30868713
http://dx.doi.org/10.1111/acel.12928

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