IL‐1α cleavage by inflammatory caspases of the noncanonical inflammasome controls the senescence‐associated secretory phenotype

Interleukin‐1 alpha (IL‐1α) is a powerful cytokine that modulates immunity, and requires canonical cleavage by calpain for full activity. Mature IL‐1α is produced after inflammasome activation and during cell senescence, but the protease cleaving IL‐1α in these contexts is unknown. We show IL‐1α is...

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Detalles Bibliográficos
Autores principales: Wiggins, Kimberley A., Parry, Aled J., Cassidy, Liam D., Humphry, Melanie, Webster, Steve J., Goodall, Jane C., Narita, Masashi, Clarke, Murray C. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516163/
https://www.ncbi.nlm.nih.gov/pubmed/30916891
http://dx.doi.org/10.1111/acel.12946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516163/
https://www.ncbi.nlm.nih.gov/pubmed/30916891
http://dx.doi.org/10.1111/acel.12946

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