SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long‐lived Myc hypomorphic mice

Mice that express reduced levels of the c‐Myc gene (Myc (+/−) heterozygotes) are long‐lived. Myc hypomorphic mice display reduced rates of protein translation and decreased activity of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). Given the prominent effect of mTOR on aging, lower mTO...

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Detalles Bibliográficos
Autores principales: Zhao, Xiaoai, Petrashen, Anna P., Sanders, Jennifer A., Peterson, Abigail L., Sedivy, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516164/
https://www.ncbi.nlm.nih.gov/pubmed/30909319
http://dx.doi.org/10.1111/acel.12947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516164/
https://www.ncbi.nlm.nih.gov/pubmed/30909319
http://dx.doi.org/10.1111/acel.12947

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