Systemic clearance of p16(INK4a)‐positive senescent cells mitigates age‐associated intervertebral disc degeneration

RATIONALE: Age‐related changes in the intervertebral discs are the predominant contributors to back pain, a common physical and functional impairment experienced by older persons. Cellular senescence, a process wherein cells undergo growth arrest and chronically secrete numerous inflammatory molecul...

Descripción completa

Detalles Bibliográficos
Autores principales: Patil, Prashanti, Dong, Qing, Wang, Dong, Chang, Jianhui, Wiley, Christopher, Demaria, Marco, Lee, Joon, Kang, James, Niedernhofer, Laura J., Robbins, Paul D., Sowa, Gwendolyn, Campisi, Judith, Zhou, Daohong, Vo, Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516165/
https://www.ncbi.nlm.nih.gov/pubmed/30900385
http://dx.doi.org/10.1111/acel.12927

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516165/
https://www.ncbi.nlm.nih.gov/pubmed/30900385
http://dx.doi.org/10.1111/acel.12927

Ejemplares similares