Noncoding variations in Cyp24a1 gene are associated with Klotho‐mediated aging phenotypes in different strains of mice

In mutant mice, reduced levels of Klotho promoted high levels of active vitamin D in the serum. Genetic or dietary manipulations that diminished active vitamin D alleviated aging‐related phenotypes caused by Klotho down‐regulation. The hypomorphic Klotho [kl/kl] allele that decreases Klotho expressi...

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Detalles Bibliográficos
Autores principales: Singh, Amit, Verma, Anjali, Sallin, Michelle A., Lang, Florian, Sen, Ranjan, Sen, Jyoti Misra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516175/
https://www.ncbi.nlm.nih.gov/pubmed/30920112
http://dx.doi.org/10.1111/acel.12949

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516175/
https://www.ncbi.nlm.nih.gov/pubmed/30920112
http://dx.doi.org/10.1111/acel.12949

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