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Dynamin‐like protein 1 cleavage by calpain in Alzheimer’s disease

Abnormal mitochondrial dynamics contributes to mitochondrial dysfunction in Alzheimer's disease (AD), yet the underlying mechanism remains elusive. In the current study, we reported that DLP1, the key mitochondrial fission GTPase, is a substrate of calpain which produced specific N‐terminal DLP...

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Detalles Bibliográficos
Autores principales: Jiang, Sirui, Shao, Changjuan, Tang, Fangqiang, Wang, Wenzhang, Zhu, Xiongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516178/
https://www.ncbi.nlm.nih.gov/pubmed/30767411
http://dx.doi.org/10.1111/acel.12912