Nonequivalence of Second Sphere “Noncatalytic” Residues in Pentaerythritol Tetranitrate Reductase in Relation to Local Dynamics Linked to H-Transfer in Reactions with NADH and NADPH Coenzymes

[Image: see text] Many enzymes that catalyze hydride transfer reactions work via a mechanism dominated by quantum mechanical tunneling. The involvement of fast vibrational modes of the reactive complex is often inferred in these reactions, as in the case of the NAD(P)H-dependent pentaerythritol tetr...

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Detalles Bibliográficos
Autores principales: Iorgu, Andreea I., Baxter, Nicola J., Cliff, Matthew J., Levy, Colin, Waltho, Jonathan P., Hay, Sam, Scrutton, Nigel S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516726/
https://www.ncbi.nlm.nih.gov/pubmed/31119061
http://dx.doi.org/10.1021/acscatal.8b02810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516726/
https://www.ncbi.nlm.nih.gov/pubmed/31119061
http://dx.doi.org/10.1021/acscatal.8b02810

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