Threshold for Pre-existing Antibody Levels Limiting Transduction Efficiency of Systemic rAAV9 Gene Delivery: Relevance for Translation

Widespread anti-AAV antibodies (Abs) in humans pose a critical challenge for the translation of AAV gene therapies, limiting patient eligibility. In this study, non-human primates (NHPs) with pre-existing αAAV Abs were used to investigate the impact of αAAV9 Ab levels on the transduction efficiency...

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Detalles Bibliográficos
Autores principales: Meadows, Aaron S., Pineda, Ricardo J., Goodchild, Laurie, Bobo, Tierra A., Fu, Haiyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517378/
https://www.ncbi.nlm.nih.gov/pubmed/31193101
http://dx.doi.org/10.1016/j.omtm.2019.04.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517378/
https://www.ncbi.nlm.nih.gov/pubmed/31193101
http://dx.doi.org/10.1016/j.omtm.2019.04.004

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