Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge

Neonatal Fc-receptor (FcRn), the major histocompatibility complex (MHC) class I-like Fc-receptor, transports immunoglobuline G (IgG) across cell layers, extending IgG half-life in circulation and providing newborns with humoral immunity. IgG1 and IgG2 have similar half-lives, yet IgG2 displays lower...

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Detalles Bibliográficos
Autores principales: Stapleton, Nigel M., Brinkhaus, Maximilian, Armour, Kathryn L., Bentlage, Arthur E. H., de Taeye, Steven W., Temming, A. Robin, Mok, Juk Yee, Brasser, Giso, Maas, Marielle, van Esch, Wim J. E., Clark, Mike R., Williamson, Lorna M., van der Schoot, C. Ellen, Vidarsson, Gestur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517591/
https://www.ncbi.nlm.nih.gov/pubmed/31089170
http://dx.doi.org/10.1038/s41598-019-40731-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517591/
https://www.ncbi.nlm.nih.gov/pubmed/31089170
http://dx.doi.org/10.1038/s41598-019-40731-2

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