Novel Small Molecule MEK Inhibitor URML-3881 Enhances Cisplatin Sensitivity in Clear Cell Ovarian Cancer

Advanced clear cell ovarian cancer (CCOC) is a highly fatal malignancy with a scarcity of effective treatment options. CCOC is inherently chemotherapy resistance, but the exact mechanism of this resistance has yet to be established. Prosurvival signaling, such as through the MAPK cascade, is one way...

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Detalles Bibliográficos
Autores principales: Rowswell-Turner, Rachael B., Rutishauser, Jennifer A., Kim, Kyu Kwang, Khazan, Negar, Sivagnanalingam, Umayal, Jones, Aaron M., Singh, Rakesh K., Moore, Richard G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517847/
https://www.ncbi.nlm.nih.gov/pubmed/31082584
http://dx.doi.org/10.1016/j.tranon.2019.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517847/
https://www.ncbi.nlm.nih.gov/pubmed/31082584
http://dx.doi.org/10.1016/j.tranon.2019.04.009

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