Cargando…

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of β-cell m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vethe, Heidrun, Ghila, Luiza, Berle, Magnus, Hoareau, Laurence, Haaland, Øystein A., Scholz, Hanne, Paulo, Joao A., Chera, Simona, Ræder, Helge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518024/ https://www.ncbi.nlm.nih.gov/pubmed/31139151 http://dx.doi.org/10.3389/fendo.2019.00293

Ejemplares similares

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells
por: Vethe, Heidrun, et al.
Publicado: (2017)

Bioinformatic Analyses of miRNA–mRNA Signature during hiPSC Differentiation towards Insulin-Producing Cells upon HNF4α Mutation
por: Ghila, Luiza, et al.
Publicado: (2020)

Chronically Elevated Exogenous Glucose Elicits Antipodal Effects on the Proteome Signature of Differentiating Human iPSC-Derived Pancreatic Progenitors
por: Ghila, Luiza, et al.
Publicado: (2021)

Reprogrammed Cells Display Distinct Proteomic Signatures Associated with Colony Morphology Variability
por: Bjørlykke, Yngvild, et al.
Publicado: (2019)

Encapsulation boosts islet-cell signature in differentiating human induced pluripotent stem cells via integrin signalling
por: Legøy, Thomas Aga, et al.
Publicado: (2020)

Novel protein signatures suggest progression to muscular invasiveness in bladder cancer
por: Berle, Magnus, et al.
Publicado: (2018)

In vivo Environment Swiftly Restricts Human Pancreatic Progenitors Toward Mono-Hormonal Identity via a HNF1A/HNF4A Mechanism
por: Legøy, Thomas Aga, et al.
Publicado: (2020)

Editorial: Beta-Cell Fate: From Gene Circuits to Disease Mechanisms
por: Ghila, Luiza, et al.
Publicado: (2022)

Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
por: Carrasco, Manuel, et al.
Publicado: (2022)

Maturing iPSC-Derived Cardiomyocytes
por: Tang, Bor Luen
Publicado: (2020)

Pro-maturational Effects of Human iPSC-Derived Cortical Astrocytes upon iPSC-Derived Cortical Neurons
por: Hedegaard, Anne, et al.
Publicado: (2020)

Diabetes Relief in Mice by Glucose-Sensing Insulin-Secreting Human α-Cells
por: Furuyama, Kenichiro, et al.
Publicado: (2019)

Applications of iPSC-derived beta cells from patients with diabetes
por: Maxwell, Kristina G., et al.
Publicado: (2021)

Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells
por: Zhao, Kaixuan, et al.
Publicado: (2022)

Organ-Chips Enhance the Maturation of Human iPSC-Derived Dopamine Neurons
por: Otero, Maria G., et al.
Publicado: (2023)

Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons
por: Emperador Melero, Javier, et al.
Publicado: (2017)

Characterization of cytoskeleton features and maturation status of cultured human iPSC-derived cardiomyocytes
por: Zuppinger, Christian, et al.
Publicado: (2017)

Metabolic Maturation Media Improve Physiological Function of Human iPSC-Derived Cardiomyocytes
por: M. Feyen, Dries A., et al.
Publicado: (2020)

Distinct and Dynamic Transcriptome Adaptations of iPSC-Generated Astrocytes after Cytokine Stimulation
por: Spreng, Anna-Sophie, et al.
Publicado: (2022)

Banking on iPSC- Is it Doable and is it Worthwhile
por: Solomon, Susan, et al.
Publicado: (2014)

Roadblocks in the Path of iPSC to the Clinic
por: Garreta, Elena, et al.
Publicado: (2018)

iPSC Bioprinting: Where are We at?
por: Romanazzo, Sara, et al.
Publicado: (2019)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

Optimizing maturity and dose of iPSC-derived dopamine progenitor cell therapy for Parkinson’s disease
por: Hiller, Benjamin M., et al.
Publicado: (2022)

ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes
por: Miki, Kenji, et al.
Publicado: (2021)

Characterization of cardiac metabolism in iPSC-derived cardiomyocytes: lessons from maturation and disease modeling
por: Vučković, Sofija, et al.
Publicado: (2022)

Metabolic Maturation Increases Susceptibility to Hypoxia-induced Damage in Human iPSC-derived Cardiomyocytes
por: Peters, Marijn C, et al.
Publicado: (2022)

Improvements in Maturity and Stability of 3D iPSC-Derived Hepatocyte-like Cell Cultures
por: Suominen, Siiri, et al.
Publicado: (2023)

Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
por: Xu, Ranjie, et al.
Publicado: (2020)

NOCICEPTRA: Gene and microRNA Signatures and Their Trajectories Characterizing Human iPSC‐Derived Nociceptor Maturation
por: Zeidler, Maximilian, et al.
Publicado: (2021)

Generation of Human iPSC-Derived Astrocytes with a mature star-shaped phenotype for CNS modeling
por: Voulgaris, Dimitrios, et al.
Publicado: (2022)

Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson’s iPSC-dopamine neurons
por: Beccano-Kelly, Dayne A., et al.
Publicado: (2023)

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons
por: Lin, Waka, et al.
Publicado: (2023)

iPSC-based model of viral infection
Publicado: (2012)

Chromatin looping is needed for iPSC induction
por: Hu, Ji-Fan, et al.
Publicado: (2014)

iPSC-MSCs and islet allograft tolerance
por: Wang, Tong-Song, et al.
Publicado: (2015)

Human iPSC banking: barriers and opportunities
por: Huang, Ching-Ying, et al.
Publicado: (2019)

Application of iPSC to Modelling of Respiratory Diseases
por: Calvert, Ben A., et al.
Publicado: (2020)

The Utilisation of Hydrogels for iPSC-Cardiomyocyte Research
por: Patel, Leena, et al.
Publicado: (2023)

Altered Differentiation Potential of Gaucher’s Disease iPSC Neuronal Progenitors due to Wnt/β-Catenin Downregulation
por: Awad, Ola, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_t4t8lhm06q9i48oe4g4upbmm1r