An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice

AIMS/HYPOTHESIS: Glucose-dependent insulinotropic polypeptide (GIP) and xenin, regulatory gut hormones secreted from enteroendocrine K cells, exert important effects on metabolism. In addition, xenin potentiates the biological actions of GIP. The present study assessed the actions and therapeutic ut...

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Detalles Bibliográficos
Autores principales: Hasib, Annie, Ng, Ming T., Gault, Victor A., Khan, Dawood, Parthsarathy, Vadivel, Flatt, Peter R., Irwin, Nigel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518372/
https://www.ncbi.nlm.nih.gov/pubmed/28004148
http://dx.doi.org/10.1007/s00125-016-4186-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518372/
https://www.ncbi.nlm.nih.gov/pubmed/28004148
http://dx.doi.org/10.1007/s00125-016-4186-y

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