Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

INTRODUCTION: Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently underg...

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Detalles Bibliográficos
Autores principales: Grinde, Maria T., Hilmarsdottir, Bylgja, Tunset, Hanna Maja, Henriksen, Ida Marie, Kim, Jana, Haugen, Mads H., Rye, Morten Beck, Mælandsmo, Gunhild M., Moestue, Siver A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518522/
https://www.ncbi.nlm.nih.gov/pubmed/31088535
http://dx.doi.org/10.1186/s13058-019-1141-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518522/
https://www.ncbi.nlm.nih.gov/pubmed/31088535
http://dx.doi.org/10.1186/s13058-019-1141-0

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