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Glutamine to proline conversion is associated with response to glutaminase inhibition in breast cancer

INTRODUCTION: Glutaminase inhibitors target cancer cells by blocking the conversion of glutamine to glutamate, thereby potentially interfering with anaplerosis and synthesis of amino acids and glutathione. The drug CB-839 has shown promising effects in preclinical experiments and is currently underg...

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Detalles Bibliográficos
Autores principales:	Grinde, Maria T., Hilmarsdottir, Bylgja, Tunset, Hanna Maja, Henriksen, Ida Marie, Kim, Jana, Haugen, Mads H., Rye, Morten Beck, Mælandsmo, Gunhild M., Moestue, Siver A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518522/ https://www.ncbi.nlm.nih.gov/pubmed/31088535 http://dx.doi.org/10.1186/s13058-019-1141-0

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