Combination peptide immunotherapy suppresses antibody and helper T-cell responses to the major human platelet autoantigen glycoprotein IIb/IIIa in HLA-transgenic mice

Platelet destruction in immune thrombocytopenia is caused by autoreactive antibody and T-cell responses, most commonly directed against platelet glycoprotein IIb/IIIa. Loss of self-tolerance in the disease is also associated with deficient activity of regulatory T cells. Having previously mapped sev...

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Detalles Bibliográficos
Autores principales: Hall, Lindsay S., Lennon, Charlotte S., Hall, Andrew M., Urbaniak, Stanislaw J., Vickers, Mark A., Barker, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518892/
https://www.ncbi.nlm.nih.gov/pubmed/30514805
http://dx.doi.org/10.3324/haematol.2017.179424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518892/
https://www.ncbi.nlm.nih.gov/pubmed/30514805
http://dx.doi.org/10.3324/haematol.2017.179424

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