The small-molecule compound AC-73 targeting CD147 inhibits leukemic cell proliferation, induces autophagy and increases the chemotherapeutic sensitivity of acute myeloid leukemia cells

CD147 is a transmembrane glycoprotein with multiple functions in human healthy tissues and diseases, in particular in cancer. Overexpression of CD147 correlates with biological functions that promote tumor progression and confers resistance to chemotherapeutic drugs. In contrast to solid tumors, the...

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Detalles Bibliográficos
Autores principales: Spinello, Isabella, Saulle, Ernestina, Quaranta, Maria Teresa, Pasquini, Luca, Pelosi, Elvira, Castelli, Germana, Ottone, Tiziana, Voso, Maria Teresa, Testa, Ugo, Labbaye, Catherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518905/
https://www.ncbi.nlm.nih.gov/pubmed/30467201
http://dx.doi.org/10.3324/haematol.2018.199661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518905/
https://www.ncbi.nlm.nih.gov/pubmed/30467201
http://dx.doi.org/10.3324/haematol.2018.199661

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