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Cellular polarity modulates drug resistance in primary colorectal cancers via orientation of the multidrug resistance protein ABCB1

Colonic epithelial cells are highly polarised with a lumen‐facing apical membrane, termed the brush border, and a basal membrane in contact with the underlying extracellular matrix (ECM). This polarity is often maintained in cancer tissue in the form of neoplastic glands and has prognostic value. We...

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Detalles Bibliográficos
Autores principales: Ashley, Neil, Ouaret, Djamila, Bodmer, Walter F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519031/
https://www.ncbi.nlm.nih.gov/pubmed/30306567
http://dx.doi.org/10.1002/path.5179