Disruption of sialic acid metabolism drives tumor growth by augmenting CD8(+) T cell apoptosis

Sialylated glycan structures are known for their immunomodulatory capacities and their contribution to tumor immune evasion. However, the role of aberrant sialylation in colorectal cancer and the consequences of complete tumor desialylation on anti‐tumor immunity remain unstudied. Here, we report th...

Descripción completa

Detalles Bibliográficos
Autores principales: Cornelissen, Lenneke A.M., Blanas, Athanasios, van der Horst, Joost C., Kruijssen, Laura, Zaal, Anouk, O'Toole, Tom, Wiercx, Lieke, van Kooyk, Yvette, van Vliet, Sandra J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Tumor Immunology and Microenvironment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519079/
https://www.ncbi.nlm.nih.gov/pubmed/30578646
http://dx.doi.org/10.1002/ijc.32084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519079/
https://www.ncbi.nlm.nih.gov/pubmed/30578646
http://dx.doi.org/10.1002/ijc.32084

Ejemplares similares