Humanised monoclonal antibodies neutralise pertussis toxin by receptor blockade and reduced retrograde trafficking

Pertussis toxin (PTx) is a major protective antigen produced by Bordetella pertussis that is included in all current acellular vaccines. Of several well‐characterized monoclonal antibodies binding this toxin, the humanised hu1B7 and hu11E6 antibodies are highly protective in multiple in vitro and in...

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Detalles Bibliográficos
Autores principales: Acquaye‐Seedah, Edith, Huang, Yimin, Sutherland, Jamie N., DiVenere, Andrea M., Maynard, Jennifer A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519169/
https://www.ncbi.nlm.nih.gov/pubmed/30152075
http://dx.doi.org/10.1111/cmi.12948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519169/
https://www.ncbi.nlm.nih.gov/pubmed/30152075
http://dx.doi.org/10.1111/cmi.12948

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