Short Convergent Synthesis of the Mycolactone Core Through Lithiation–Borylation Homologations

Using iterative lithiation–borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17 % overall yield. The rapid build‐up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.

Detalles Bibliográficos
Autores principales: Brown, Christopher A., Aggarwal, Varinder K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY‐VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519258/
https://www.ncbi.nlm.nih.gov/pubmed/26332797
http://dx.doi.org/10.1002/chem.201503122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519258/
https://www.ncbi.nlm.nih.gov/pubmed/26332797
http://dx.doi.org/10.1002/chem.201503122

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