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Short Convergent Synthesis of the Mycolactone Core Through Lithiation–Borylation Homologations
Using iterative lithiation–borylation homologations, the mycolactone toxin core has been synthesized in 13 steps and 17 % overall yield. The rapid build‐up of molecular complexity, high convergence and high stereoselectivity are noteworthy features of this synthesis.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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WILEY‐VCH Verlag
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519258/ https://www.ncbi.nlm.nih.gov/pubmed/26332797 http://dx.doi.org/10.1002/chem.201503122 |