PDEδ inhibition impedes the proliferation and survival of human colorectal cancer cell lines harboring oncogenic KRas

Ras proteins, most notably KRas, are prevalent oncogenes in human cancer. Plasma membrane localization and thereby signaling of KRas is regulated by the prenyl‐binding protein PDEδ. Recently, we have reported the specific anti‐proliferative effects of PDEδ inhibition in KRas‐dependent human pancreat...

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Detalles Bibliográficos
Autores principales: Klein, Christian H., Truxius, Dina C., Vogel, Holger A., Harizanova, Jana, Murarka, Sandip, Martín‐Gago, Pablo, Bastiaens, Philippe I.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Molecular Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519276/
https://www.ncbi.nlm.nih.gov/pubmed/30194764
http://dx.doi.org/10.1002/ijc.31859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519276/
https://www.ncbi.nlm.nih.gov/pubmed/30194764
http://dx.doi.org/10.1002/ijc.31859

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