Localization of active endogenous and exogenous β‐glucocerebrosidase by correlative light‐electron microscopy in human fibroblasts

β‐Glucocerebrosidase (GBA) is the enzyme that degrades glucosylceramide in lysosomes. Defects in GBA that result in overall loss of enzymatic activity give rise to the lysosomal storage disorder Gaucher disease, which is characterized by the accumulation of glucosylceramide in tissue macrophages. Ga...

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Detalles Bibliográficos
Autores principales: van Meel, Eline, Bos, Erik, van der Lienden, Martijn J. C., Overkleeft, Herman S., van Kasteren, Sander I., Koster, Abraham J., Aerts, Johannes M. F. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons A/S 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519279/
https://www.ncbi.nlm.nih.gov/pubmed/30895685
http://dx.doi.org/10.1111/tra.12641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519279/
https://www.ncbi.nlm.nih.gov/pubmed/30895685
http://dx.doi.org/10.1111/tra.12641

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