Genetic lesioning of histamine neurons increases sleep–wake fragmentation and reveals their contribution to modafinil-induced wakefulness

Acute chemogenetic inhibition of histamine (HA) neurons in adult mice induced nonrapid eye movement (NREM) sleep with an increased delta power. By contrast, selective genetic lesioning of HA neurons with caspase in adult mice exhibited a normal sleep–wake cycle overall, except at the diurnal start o...

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Detalles Bibliográficos
Autores principales: Yu, Xiao, Ma, Ying, Harding, Edward C, Yustos, Raquel, Vyssotski, Alexei L, Franks, Nicholas P, Wisden, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Basic Science of Sleep and Circadian Rhythms
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519916/
https://www.ncbi.nlm.nih.gov/pubmed/30722053
http://dx.doi.org/10.1093/sleep/zsz031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519916/
https://www.ncbi.nlm.nih.gov/pubmed/30722053
http://dx.doi.org/10.1093/sleep/zsz031

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