Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients

Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington’s disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegenerat...

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Detalles Bibliográficos
Autores principales: Pierzynowska, Karolina, Gaffke, Lidia, Cyske, Zuzanna, Węgrzyn, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520327/
https://www.ncbi.nlm.nih.gov/pubmed/30850940
http://dx.doi.org/10.1007/s11011-019-00405-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520327/
https://www.ncbi.nlm.nih.gov/pubmed/30850940
http://dx.doi.org/10.1007/s11011-019-00405-4

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