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Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients
Mutations in the HTT gene, consisting of expansion of CAG triplets, cause the Huntington’s disease (HD), one of the major neurodegenerative disorders. Formation of aggregates of mutant huntingtin (mHTT, the product of the mutant HTT gene) leads to cellular dysfunctions, and subsequent neurodegenerat...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520327/ https://www.ncbi.nlm.nih.gov/pubmed/30850940 http://dx.doi.org/10.1007/s11011-019-00405-4 |