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Development of a ribonuclease containing a G4-specific binding motif for programmable RNA cleavage
We developed a ribonuclease for site-specific targeting and cleavage of single-stranded RNA. The engineered RNase protein was constructed by incorporating two independent functional domains, an RNase HI domain that could cleave the RNA strand in a DNA-RNA hybrid, and a domain of the RHAU protein tha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520340/ https://www.ncbi.nlm.nih.gov/pubmed/31092834 http://dx.doi.org/10.1038/s41598-019-42143-8 |