Cargando…

Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer

TP53 mutations are common in colorectal cancer (CRC). Most TP53 sequencing studies have been restricted to coding regions, but recent studies have revealed that splice mutations can generate transcript variants with distinct tumorigenic and prognostic properties. Here, we performed unrestricted sequ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Smeby, Jørgen, Sveen, Anita, Eilertsen, Ina A., Danielsen, Stine A., Hoff, Andreas M., Eide, Peter W., Johannessen, Bjarne, Hektoen, Merete, Skotheim, Rolf I., Guren, Marianne G., Nesbakken, Arild, Lothe, Ragnhild A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520361/ https://www.ncbi.nlm.nih.gov/pubmed/31092812 http://dx.doi.org/10.1038/s41389-019-0141-3

Ejemplares similares

Exploratory analyses of consensus molecular subtype-dependent associations of TP53 mutations with immunomodulation and prognosis in colorectal cancer
por: Smeby, Jørgen, et al.
Publicado: (2019)

Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity
por: Smeby, Jørgen, et al.
Publicado: (2020)

Alternative splicing expands the prognostic impact of KRAS in microsatellite stable primary colorectal cancer
por: Eilertsen, Ina A., et al.
Publicado: (2018)

CMS-dependent prognostic impact of KRAS and BRAF(V600E) mutations in primary colorectal cancer
por: Smeby, J, et al.
Publicado: (2018)

Prediction of relapse-free survival according to adjuvant chemotherapy and regulator of chromosome condensation 2 (RCC2) expression in colorectal cancer
por: Bergsland, Christian H, et al.
Publicado: (2020)

Transcriptome instability in colorectal cancer identified by exon microarray analyses: Associations with splicing factor expression levels and patient survival
por: Sveen, Anita, et al.
Publicado: (2011)

Multilevel genomics of colorectal cancers with microsatellite instability—clinical impact of JAK1 mutations and consensus molecular subtype 1
por: Sveen, Anita, et al.
Publicado: (2017)

The expressed mutational landscape of microsatellite stable colorectal cancers
por: Sveen, Anita, et al.
Publicado: (2021)

Genomic and prognostic heterogeneity among RAS/BRAF (V600E)/TP53 co‐mutated resectable colorectal liver metastases
por: Berg, Kaja C. G., et al.
Publicado: (2021)

Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies
por: Berg, Kaja C. G., et al.
Publicado: (2017)

Novel RNA variants in colorectal cancers
por: Hoff, Andreas M., et al.
Publicado: (2015)

Phospholipase C Isozymes Are Deregulated in Colorectal Cancer – Insights Gained from Gene Set Enrichment Analysis of the Transcriptome
por: Danielsen, Stine A., et al.
Publicado: (2011)

Identification of an epigenetic biomarker panel with high sensitivity and specificity for colorectal cancer and adenomas
por: Lind, Guro E, et al.
Publicado: (2011)

Prognostic, predictive, and pharmacogenomic assessments of CDX2 refine stratification of colorectal cancer
por: Bruun, Jarle, et al.
Publicado: (2018)

Long noncoding RNA MIR31HG is a bona fide prognostic marker with colorectal cancer cell‐intrinsic properties
por: Eide, Peter W., et al.
Publicado: (2019)

Transcriptome instability as a molecular pan-cancer characteristic of carcinomas
por: Sveen, Anita, et al.
Publicado: (2014)

De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity
por: Moosavi, Seyed H., et al.
Publicado: (2021)

Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains
por: Berg, Kaja C. G., et al.
Publicado: (2019)

Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer
por: Eide, Peter W., et al.
Publicado: (2021)

Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases
por: Kryeziu, Kushtrim, et al.
Publicado: (2021)

CpG island methylator phenotype identifies high risk patients among microsatellite stable BRAF mutated colorectal cancers
por: Vedeld, Hege Marie, et al.
Publicado: (2017)

A Tissue-Based Comparative Effectiveness Analysis of Biomarkers for Early Detection of Colorectal Tumors
por: Ahmed, Deeqa, et al.
Publicado: (2012)

E‐cadherin is a robust prognostic biomarker in colorectal cancer and low expression is associated with sensitivity to inhibitors of topoisomerase, aurora, and HSP90 in preclinical models
por: Bruun, Jarle, et al.
Publicado: (2021)

Epigenetic and genetic features of 24 colon cancer cell lines
por: Ahmed, D, et al.
Publicado: (2013)

Spatial analysis and CD25-expression identify regulatory T cells as predictors of a poor prognosis in colorectal cancer
por: Bergsland, Christian H., et al.
Publicado: (2022)

High Frequency of Fusion Transcripts Involving TCF7L2 in Colorectal Cancer: Novel Fusion Partner and Splice Variants
por: Nome, Torfinn, et al.
Publicado: (2014)

TIN: An R Package for Transcriptome Instability Analysis
por: Johannessen, Bjarne, et al.
Publicado: (2015)

DNA Sequence Profiles of the Colorectal Cancer Critical Gene Set KRAS-BRAF-PIK3CA-PTEN-TP53 Related to Age at Disease Onset
por: Berg, Marianne, et al.
Publicado: (2010)

Re-assessing ZNF331 as a DNA methylation biomarker for colorectal cancer
por: Vedeld, Hege Marie, et al.
Publicado: (2018)

CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models
por: Eide, Peter W., et al.
Publicado: (2017)

Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci
por: Berg, Marianne, et al.
Publicado: (2010)

Prognostic Significance of β-Catenin, E-Cadherin, and SOX9 in Colorectal Cancer: Results from a Large Population-Representative Series
por: Bruun, Jarle, et al.
Publicado: (2014)

Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors
por: Kolberg, Matthias, et al.
Publicado: (2017)

Somatic mutations reveal complex metastatic seeding from multifocal primary prostate cancer
por: Carm, Kristina T., et al.
Publicado: (2022)

Digital image analysis of multiplex fluorescence IHC in colorectal cancer recognizes the prognostic value of CDX2 and its negative correlation with SOX2
por: Lopes, Nair, et al.
Publicado: (2019)

MicroRNAs as growth regulators, their function and biomarker status in colorectal cancer
por: Cekaite, Lina, et al.
Publicado: (2015)

Correction: Tumour-infiltrating CD8(+) lymphocytes and colorectal cancer recurrence by tumour and nodal stage
por: Glaire, Mark A., et al.
Publicado: (2019)

Tumour-infiltrating CD8(+) lymphocytes and colorectal cancer recurrence by tumour and nodal stage
por: Glaire, Mark A., et al.
Publicado: (2019)

Comparison of chromosomal and array-based comparative genomic hybridization for the detection of genomic imbalances in primary prostate carcinomas
por: Ribeiro, Franclim R, et al.
Publicado: (2006)

Frequent copy number gains of SLC2A3 and ETV1 in testicular embryonal carcinomas
por: Hoff, Andreas M, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_gpa2rvouq2sod089ih4ippr2ut