Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats

Short biologic half-lives limit the therapeutic utility of many small molecules. One approach to extending the half-life of pharmacologically active small molecules is conjugation to less degradable nanoparticles; here we report the synthesis and activity of six targeted polymeric (PEG-b-PLA) nanopa...

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Detalles Bibliográficos
Autores principales: Liu, Xiuling, Corciulo, Carmen, Arabagian, Stephanie, Ulman, Abraham, Cronstein, Bruce N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520388/
https://www.ncbi.nlm.nih.gov/pubmed/31092864
http://dx.doi.org/10.1038/s41598-019-43834-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520388/
https://www.ncbi.nlm.nih.gov/pubmed/31092864
http://dx.doi.org/10.1038/s41598-019-43834-y

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