Third BIR domain of XIAP binds to both Cu(II) and Cu(I) in multiple sites and with diverse affinities characterized at atomic resolution

The X-chromosome linked inhibitor of apoptosis, XIAP, is mainly known as the inhibitor of caspases by direct interaction with caspases with its baculoviral IAP repeat (BIR) domains. XIAP has three BIR domains and each BIR domain contains a zinc binding site, normally known as zinc finger motif. Rece...

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Detalles Bibliográficos
Autores principales: Chen, Shen-Na, Fang, Tian, Kong, Jing-Yang, Pan, Bin-Bin, Su, Xun-Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520397/
https://www.ncbi.nlm.nih.gov/pubmed/31092843
http://dx.doi.org/10.1038/s41598-019-42875-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520397/
https://www.ncbi.nlm.nih.gov/pubmed/31092843
http://dx.doi.org/10.1038/s41598-019-42875-7

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