In vitro and in vivo Metabolism of a Potent Inhibitor of Soluble Epoxide Hydrolase, 1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea

1-(1-Propionylpiperidin-4-yl)-3-(4-(trifluoromethoxy)phenyl)urea (TPPU) is a potent soluble epoxide hydrolase (sEH) inhibitor that is used extensively in research for modulating inflammation and protecting against hypertension, neuropathic pain, and neurodegeneration. Despite its wide use in various...

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Detalles Bibliográficos
Autores principales: Wan, Debin, Yang, Jun, McReynolds, Cindy B., Barnych, Bogdan, Wagner, Karen M., Morisseau, Christophe, Hwang, Sung Hee, Sun, Jia, Blöcher, René, Hammock, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520522/
https://www.ncbi.nlm.nih.gov/pubmed/31143115
http://dx.doi.org/10.3389/fphar.2019.00464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520522/
https://www.ncbi.nlm.nih.gov/pubmed/31143115
http://dx.doi.org/10.3389/fphar.2019.00464

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