Determination and analysis of agonist and antagonist potential of naturally occurring flavonoids for estrogen receptor (ERα) by various parameters and molecular modelling approach

Most estrogen receptor α (ERα) ligands target the ligand binding domain (LBD). Agonist 17β-estradiol (E(2)) and tamoxifen (TM, known SERM), bind to the same site within the LBD. However, structures of ligand-bound complexes show that E(2) and TM induce different conformations of helix 12 (H12). Duri...

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Detalles Bibliográficos
Autores principales: Puranik, Ninad V., Srivastava, Pratibha, Bhatt, Gaurav, John Mary, Dixcy Jaba Sheeba, Limaye, Anil M., Sivaraman, Jayanthi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520524/
https://www.ncbi.nlm.nih.gov/pubmed/31092862
http://dx.doi.org/10.1038/s41598-019-43768-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520524/
https://www.ncbi.nlm.nih.gov/pubmed/31092862
http://dx.doi.org/10.1038/s41598-019-43768-5

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