Cargando…

Thiamine and benfotiamine protect neuroblastoma cells against paraquat and β-amyloid toxicity by a coenzyme-independent mechanism

BACKGROUND: Benfotiamine (BFT) is a synthetic thiamine precursor with high bioavailability. It is efficient in treating complications of type 2 diabetes and has beneficial effects in mouse models of neurodegenerative diseases. The mechanism of action of BFT remains unknown, though it is sometimes su...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sambon, Margaux, Napp, Aurore, Demelenne, Alice, Vignisse, Julie, Wins, Pierre, Fillet, Marianne, Bettendorff, Lucien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520661/ https://www.ncbi.nlm.nih.gov/pubmed/31193162 http://dx.doi.org/10.1016/j.heliyon.2019.e01710

Ejemplares similares

Neuroprotective Effects of Thiamine and Precursors with Higher Bioavailability: Focus on Benfotiamine and Dibenzoylthiamine
por: Sambon, Margaux, et al.
Publicado: (2021)

Dibenzoylthiamine Has Powerful Antioxidant and Anti-Inflammatory Properties in Cultured Cells and in Mouse Models of Stress and Neurodegeneration
por: Sambon, Margaux, et al.
Publicado: (2020)

Adenylate kinase-independent thiamine triphosphate accumulation under severe energy stress in Escherichia coli
por: Gigliobianco, Tiziana, et al.
Publicado: (2008)

Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives
por: Volvert, Marie-Laure, et al.
Publicado: (2008)

Thiamine and benfotiamine: Focus on their therapeutic potential
por: Bozic, Iva, et al.
Publicado: (2023)

Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress
por: Gigliobianco, Tiziana, et al.
Publicado: (2010)

Thiamine Status in Humans and Content of Phosphorylated Thiamine Derivatives in Biopsies and Cultured Cells
por: Gangolf, Marjorie, et al.
Publicado: (2010)

Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine
por: Hurt, Julie K., et al.
Publicado: (2012)

An alternative role of F(o)F(1)-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate
por: Gigliobianco, Tiziana, et al.
Publicado: (2013)

Paraptosis Cell Death Induction by the Thiamine Analog Benfotiamine in Leukemia Cells
por: Sugimori, Naomi, et al.
Publicado: (2015)

Update on Thiamine Triphosphorylated Derivatives and Metabolizing Enzymatic Complexes
por: Bettendorff, Lucien
Publicado: (2021)

Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis
por: Mkrtchyan, Garik, et al.
Publicado: (2015)

Solubility enhancement of benfotiamine, a lipid derivative of thiamine by solid dispersion technique
por: Patel, S. M., et al.
Publicado: (2012)

Synthetic Thioesters of Thiamine: Promising Tools for Slowing Progression of Neurodegenerative Diseases †
por: Bettendorff, Lucien
Publicado: (2023)

Thiamine diphosphate adenylyl transferase from E. coli: functional characterization of the enzyme synthesizing adenosine thiamine triphosphate
por: Makarchikov, Alexander F, et al.
Publicado: (2007)

High Inorganic Triphosphatase Activities in Bacteria and Mammalian Cells: Identification of the Enzymes Involved
por: Kohn, Gregory, et al.
Publicado: (2012)

Impaired Thiamine Metabolism in Amyotrophic Lateral Sclerosis and Its Potential Treatment With Benfotiamine: A Case Report and a Review of the Literature
por: Mann, Richard H
Publicado: (2023)

Preventive effects of benfotiamine in chronic diabetic complications
por: Chakrabarti, Rana, et al.
Publicado: (2011)

The coenzyme thiamine diphosphate displays a daily rhythm in the Arabidopsis nucleus
por: Noordally, Zeenat B., et al.
Publicado: (2020)

Benfotiamine Counteracts Smoking-Induced Vascular Dysfunction in Healthy Smokers
por: Stirban, Alin, et al.
Publicado: (2012)

Effect of Benfotiamine in Podocyte Damage Induced by Peritoneal Dialysis Fluid
por: Müller-Krebs, Sandra, et al.
Publicado: (2015)

Comparison of Three Complementary Analytical Techniques for the Evaluation of the Biosimilar Comparability of a Monoclonal Antibody and an Fc-Fusion Protein
por: Demelenne, Alice, et al.
Publicado: (2021)

Benfotiamine upregulates antioxidative system in activated BV-2 microglia cells
por: Bozic, Iva, et al.
Publicado: (2015)

Benfotiamine Attenuates Inflammatory Response in LPS Stimulated BV-2 Microglia
por: Bozic, Iva, et al.
Publicado: (2015)

Perturbation of the metabolic network in Salmonella enterica reveals cross-talk between coenzyme A and thiamine pathways
por: Ernst, Dustin C., et al.
Publicado: (2018)

Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats
por: Erdogan, Mehmet Ali, et al.
Publicado: (2018)

Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Benfotiamine in Healthy Subjects
por: Sheng, Lei, et al.
Publicado: (2021)

Effect of Benfotiamine on Advanced Glycation Endproducts and Markers of Endothelial Dysfunction and Inflammation in Diabetic Nephropathy
por: Alkhalaf, Alaa, et al.
Publicado: (2012)

Serum Metabolomic and Lipidomic Profiling Reveals Novel Biomarkers of Efficacy for Benfotiamine in Alzheimer’s Disease
por: Bhawal, Ruchika, et al.
Publicado: (2021)

Reduced Nucleotides, Thiols and O(2) in Cellular Redox Balance: A Biochemist’s View
por: Bettendorff, Lucien
Publicado: (2022)

Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs
por: Whitfield, Kyly C., et al.
Publicado: (2018)

Protective Effects of Citicoline and Benfotiamine Each Alone and in Combination on Streptozotocin-induced Memory Impairment in Mice
por: Safavi, Maryam, et al.
Publicado: (2020)

Beneficial effects of benfotiamine, a NADPH oxidase inhibitor, in isoproterenol-induced myocardial infarction in rats
por: Ahmed, Lamiaa A., et al.
Publicado: (2020)

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial on Benfotiamine Treatment in Patients With Diabetic Nephropathy
por: Alkhalaf, Alaa, et al.
Publicado: (2010)

Thiamine Diphosphate in Whole Blood, Thiamine and Thiamine Monophosphate in Breast-Milk in a Refugee Population
por: Stuetz, Wolfgang, et al.
Publicado: (2012)

Mitochondrial transport and metabolism of the vitamin B‐derived cofactors thiamine pyrophosphate, coenzyme A, FAD and NAD (+), and related diseases: A review
por: Palmieri, Ferdinando, et al.
Publicado: (2022)

Potent Radical-Scavenging Activities of Thiamin and Thiamin Diphosphate
por: Okai, Yasuji, et al.
Publicado: (2007)

PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model
por: Mouton-Liger, F, et al.
Publicado: (2015)

Paraquat (Pesticides)
Publicado: (2022)

The Time between Paraquat Ingestion and a Negative Dithionite Urine Test in an Independent Risk Factor for Death and Organ Failure in Acute Paraquat Intoxication
por: Seok, Sujin, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_3acnlbjk2ipacsr7en6mdq3nkb