Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance

A majority of breast cancer specific deaths in women with ERα (+) tumors occur due to metastases that are resistant to endocrine therapy. There is a critical need for novel therapeutic approaches to resensitize recurrent ERα (+) tumors to endocrine therapies. The objective of this study was to eluci...

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Detalles Bibliográficos
Autores principales: Kulkoyluoglu-Cotul, Eylem, Smith, Brandi Patrice, Wrobel, Kinga, Chen Zhao, Yiru, Chen, Karen Lee Ann, Hieronymi, Kadriye, Imir, Ozan Berk, Duong, Kevin, O’Callaghan, Caitlin, Mehta, Aditi, Sahoo, Sunati, Haley, Barbara, Chang, Hua, Landesman, Yosef, Madak-Erdogan, Zeynep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520695/
https://www.ncbi.nlm.nih.gov/pubmed/30987380
http://dx.doi.org/10.3390/cancers11040479

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520695/
https://www.ncbi.nlm.nih.gov/pubmed/30987380
http://dx.doi.org/10.3390/cancers11040479

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