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All the Same? The Secret Life of Prion Strains within Their Target Cells
Prions are infectious β-sheet-rich protein aggregates composed of misfolded prion protein (PrP(Sc)) that do not possess coding nucleic acid. Prions replicate by recruiting and converting normal cellular PrP(C) into infectious isoforms. In the same host species, prion strains target distinct brain re...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520713/ https://www.ncbi.nlm.nih.gov/pubmed/30970585 http://dx.doi.org/10.3390/v11040334 |