Germline Missense Variants in BRCA1: New Trends and Challenges for Clinical Annotation

Genetic testing allows for the identification of germline DNA variations, which are associated with a significant increase in the risk of developing breast cancer (BC) and ovarian cancer (OC). Detection of a BRCA1 or BRCA2 pathogenic variant triggers several clinical management actions, which may in...

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Detalles Bibliográficos
Autores principales: Golubeva, Volha A., Nepomuceno, Thales C., Monteiro, Alvaro N. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520942/
https://www.ncbi.nlm.nih.gov/pubmed/31013702
http://dx.doi.org/10.3390/cancers11040522

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520942/
https://www.ncbi.nlm.nih.gov/pubmed/31013702
http://dx.doi.org/10.3390/cancers11040522

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