Dual Targeting of Y-Box Binding Protein-1 and Akt Inhibits Proliferation and Enhances the Chemosensitivity of Colorectal Cancer Cells

KRAS-mutated colorectal cancers (CRCs) are resistant to cetuximab treatment. The multifunctional Y-box binding protein 1 (YB-1) is overexpressed in CRC and is associated with chemoresistance. In this study, the effects of oncogenic mutated KRAS(G12V) and KRAS(G13D) on YB-1 phosphorylation were inves...

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Detalles Bibliográficos
Autores principales: Maier, Eva, Attenberger, Felix, Tiwari, Aadhya, Lettau, Konstanze, Rebholz, Simone, Fehrenbacher, Birgit, Schaller, Martin, Gani, Cihan, Toulany, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521066/
https://www.ncbi.nlm.nih.gov/pubmed/31010234
http://dx.doi.org/10.3390/cancers11040562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521066/
https://www.ncbi.nlm.nih.gov/pubmed/31010234
http://dx.doi.org/10.3390/cancers11040562

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