Effects of C-Terminal Carboxylation on α-Conotoxin LsIA Interactions with Human α7 Nicotinic Acetylcholine Receptor: Molecular Simulation Studies

α-Conotoxins selectively bind to nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets due to their important role in signaling transmission in excitable cells. A previous experimental study has demonstrated that carboxylation of the C-terminal of α-conotoxin LsIA reduces its pot...

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Detalles Bibliográficos
Autores principales: Wen, Jierong, Hung, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521072/
https://www.ncbi.nlm.nih.gov/pubmed/30987002
http://dx.doi.org/10.3390/md17040206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521072/
https://www.ncbi.nlm.nih.gov/pubmed/30987002
http://dx.doi.org/10.3390/md17040206

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