Importance of TRAIL Molecular Anatomy in Receptor Oligomerization and Signaling. Implications for Cancer Therapy

(TNF)-related apoptosis-inducing ligand (TRAIL) is able to activate the extrinsic apoptotic pathway upon binding to DR4/TRAIL-R1 and/or DR5/TRAIL-R2 receptors. Structural data indicate that TRAIL functions as a trimer that can engage three receptor molecules simultaneously, resulting in receptor tri...

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Detalles Bibliográficos
Autores principales: Naval, Javier, de Miguel, Diego, Gallego-Lleyda, Ana, Anel, Alberto, Martinez-Lostao, Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521207/
https://www.ncbi.nlm.nih.gov/pubmed/30934872
http://dx.doi.org/10.3390/cancers11040444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521207/
https://www.ncbi.nlm.nih.gov/pubmed/30934872
http://dx.doi.org/10.3390/cancers11040444

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