Cargando…

Blockade of Lactate Dehydrogenase-A (LDH-A) Improves Efficacy of Anti-Programmed Cell Death-1 (PD-1) Therapy in Melanoma

Immunotherapy is a curable treatment for certain cancers, but it is still only effective in a small subset of patients. We have recently reported that programmed cell death protein-1 (PD-1) ligand (PD-L1) expression is regulated by lactate present at high levels in the tumor microenvironment (TME)....

Descripción completa

Detalles Bibliográficos
Autores principales: Daneshmandi, Saeed, Wegiel, Barbara, Seth, Pankaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521327/
https://www.ncbi.nlm.nih.gov/pubmed/30934955
http://dx.doi.org/10.3390/cancers11040450