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Time-dependent antagonist-agonist switching in receptor tyrosine kinase-mediated signaling
BACKGROUND: ErbB4/HER4 is a unique member of the ErbB family of receptor tyrosine kinases concerning its activation of anti-proliferative JAK2-STAT5 pathway when stimulated by ligand Neuregulin (NRG). Activation of this pathway leads to expression of genes like β-casein which promote cell differenti...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521356/ https://www.ncbi.nlm.nih.gov/pubmed/31092187 http://dx.doi.org/10.1186/s12859-019-2816-3 |