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Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α–induced endothelial hyperpermeability by modulating β1 integrin activation

BACKGROUND: The blood–spinal cord barrier (BSCB) is composed of a monolayer of endothelium linked with tight junctions and extracellular matrix (ECM)-rich basement membranes and is surrounded by astrocyte foot processes. Endothelial permeability is regulated by interaction between endothelial cells...

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Detalles Bibliográficos
Autores principales: Lee, Ting-Hein, Hsieh, Sung-Tsang, Chiang, Hou-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521375/
https://www.ncbi.nlm.nih.gov/pubmed/31096970
http://dx.doi.org/10.1186/s12929-019-0529-6