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Balancing sensitivity and specificity in distinguishing TCR groups by CDR sequence similarity

BACKGROUND: Repertoire sequencing is enabling deep explorations into the cellular immune response, including the characterization of commonalities and differences among T cell receptor (TCR) repertoires from different individuals, pathologies, and antigen specificities. In seeking to understand the...

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Detalles Bibliográficos
Autores principales: Thakkar, Neerja, Bailey-Kellogg, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521430/
https://www.ncbi.nlm.nih.gov/pubmed/31092185
http://dx.doi.org/10.1186/s12859-019-2864-8