Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators

The deletion of phenylalanine at position 508 (F508del) in cystic fibrosis transmembrane conductance regulator (CFTR) causes a severe defect in folding and trafficking of the chloride channel resulting in its absence at the plasma membrane of epithelial cells leading to cystic fibrosis. Progress in...

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Detalles Bibliográficos
Autores principales: de Wilde, Gert, Gees, Maarten, Musch, Sara, Verdonck, Katleen, Jans, Mia, Wesse, Anne-Sophie, Singh, Ashvani K., Hwang, Tzyh-Chang, Christophe, Thierry, Pizzonero, Mathieu, Van der Plas, Steven, Desroy, Nicolas, Cowart, Marlon, Stouten, Pieter, Nelles, Luc, Conrath, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521598/
https://www.ncbi.nlm.nih.gov/pubmed/31143125
http://dx.doi.org/10.3389/fphar.2019.00514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521598/
https://www.ncbi.nlm.nih.gov/pubmed/31143125
http://dx.doi.org/10.3389/fphar.2019.00514

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